Tell me about yourself.
Focus on relevant skills and experience. Be on guard against the interviewer who gives you free rein. Don't spend too much time answering (1-2 minutes). Avoid details. Don't ramble. Touch on four areas: Born and Raised, Education/Military Background, Work Experience, Current Situation.

[That's it.  Now it goes without saying that how you sum your life should have something to do with why you're qualified to do the job they're interested interviewing you for.]

Compliments of David E Perry and Kevin Donlin. For more creative job search tactics, go to the Guerrilla Marketing for job hunters blog and download the free audio CD.